Biolife, Volume 3, Issue 2, 2015
DOI: http://dx.doi.org/10.17812/blj2015.32.17

Research Article:




Alaa-ElDin M S Hosny1, Donia H Sheir2*, Ahmed I El-Diwany3, Nayera A M Abdelwahed4, Adyary Fallarero5 and Pia M Vuorela6

1 Department of Microbiology and Immunology, Faculty of Pharmacy, Kasr El-Aini St, POB11562, Cairo University, Cairo, Egypt
2-4Division of Pharmaceutical Industries, Department of Chemistry of Natural and Microbial Products,33 Al Behouth., POB 12311, National Research Centre, Dokki, Giza, Egypt
5-6Division of Pharmaceutical Biosciences, Faculty of Pharmacy, POB 56 (Viksbågen 5E), FI-00014,University of Helsinki, Finland

*Email: donia_sheir@yahoo.com

Abstract

Streptomyces atrovirens was isolated from soil samples in Egypt and showed broad spectrum antimicrobial activity. It was identified as Streptomyces atrovirens (strain H33) based upon16S rRNA gene sequencing. It was deposited in the GenBank database under accession number of KJ435269. Streptomyces atrovirens (strain H33)was cultivated by submerged fermentation bioreactor to produce the antimicrobialmetabolites. Purification and identification of antimicrobial compound was carried out. The antimicrobial compound exhibited low cytotoxic effect on human epithelial HL cells.

Key words:  16S rRNA, bioreactor; cytotoxicity, HPLC MS/MS, Streptomyces atrovirens H33.



Published online 15th May, 2015
© 2015 Published by Global Science Publishing Group, USA


How to Cite this Article

Alaa-ElDin M S Hosny, Donia H Sheir, Ahmed I El-Diwany, Nayera A M Abdelwahed, Adyary Fallarero and Pia M Vuorela (2015). Production and characterization of antimicrobial compound produced by Streptomyces atrovirens H33. Biolife, 3(2), pp 476-482. doi:10.17812/blj2015.32.17


Link to this article: http://biolifejournal.com/10.17812_blj2015.32.17.html
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Production and characterization of antimicrobial compound produced by Streptomyces atrovirens H33
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