Biolife
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International Quarterly Journal of Biology & Life Sciences
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Biolife, Volume 3, Issue 3, 2015
DOI: http://dx.doi.org/10.17812/blj.2015.3325

Research Article

Effect of Mesua ferrea flower and Carica papaya seed extracts on estrous Cycle of
female albino rats for Fertility and Anti fertility activity

N. Raja Naik1*, D. Malleswari2, P. Indira3

1,3 Department of Zoology, Sri Krishnadevaraya University, Anantapuramu, Andhra Pradesh, India
2 Govt. Medical College, Department of Paedeatric, Anantapuramu, Andhra Pradesh, India.

*E-mail: rajanaiknenavath@yahoo.com

ABSTRACT

Ethanol and Distilled Water extracts of Mesua ferrea (M.ferrea) flowers and Carica papaya (C.papaya) seeds were evaluated for
fertility and anti-fertility activity in adult female albino rats. Fertility and anti-fertility activity were evaluated by observing estrous
cycle.The effect of M.ferrea flower & C.papaya seed extracts on female reproductive cycle were studied in twenty four sexually
matured female albino rats with regular estrous cycle. Rats were randomly divided into four groups of six rats per each group.
Experimental groups were treated as follows: Group I (Control), Group II treated with 100 mg/kg, Group III with 200 mg/kg, Group IV
with 300 mg/kg of M.ferrea flower & C.papaya seed extract. The estrous cycle changes were determined by daily observation of
vaginal smear. There was an increase in the percentage of rats going into prolong estrous, pro-estrous, met-estrous and di-estrous
phases of the estrous cycle in all treated groups. The increase in the duration of the four phases of the cycle has a dose dependent
response. Treatment with the highest dose of the extract resulted in a significant increase in the duration of the four phases of estrus
cycle compared with the control group. Results showed that M.ferrea has the potential for use as a fertility agent for animals in future.
Similar experimentation was conducted same for anti-fertility activity by C.papaya seed extract. The decrease in the duration of the
four phases of the cycle has a dose dependent response. Treatment with the highest dose of the extract resulted in a significant
decrease in the duration of the four phases of estrous cycle compared with the control group.

Key words: Mesua ferrea, Carica papaya, fertility agent, anti-fertility agent and vaginal smear.

Published online 4 September, 2015
© 2015 Published by Global Science Publishing Group, USA

How to Cite this Article:

N. Raja Naik, D. Malleswari, P. Indira (2015 Effect of Mesua ferrea flower and Carica papaya seed extracts on estrous Cycle of female
albino rats for Fertility and Anti fertility activity Biolife, 3(3), pp 730-734. doi:10.17812/blj.2015.3325

Link to this article: http://biolifejournal.com/10.17812_blj.2015.3325.html
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