Biolife, Volume 3, Issue 3, 2015
DOI: http://dx.doi.org/10.17812/blj.2015.3310

Research Article:











ABSTRACT

Objective:
The aim of this study was to measure the level of IL-17A in the serum and synovial fluid of patients with rheumatoid arthritis and
correlated its level with disease activity.
Patients and methods:
One hundred patients suffering from rheumatoid arthritis, their ages ranged between 20 to 69 years (42.7±SD11.3). Their disease
duration ranged from 2 to 23 years (6.8±SD4.1) and fifty age and sex matched control. All patients and control were subjected to
clinical, laboratory investigation and measurement of serum IL-17A. And the patients group only were subjected to synovial fluid
IL17A by ELISA technique.
Results:
There were statistical significant increase in the serum IL17A level (p value<0.05) in the RA patients than control and in the
patients with high disease activity than those with low disease activity. There were statistical significant increases in the synovial
IL17A level in the patients with high disease activity than those with low disease activity.
Conclusion:
In our study; the mean serum IL-17A level was found with high titre in patients than control and higher in patients with high
disease activity than in those with low disease activity. The mean synovial IL-17A level was found with high titre in patients with
high disease activity than in those with low disease activity. The positive correlation between the serum and synovial IL17A in the
patients groups.

Published online 11 July, 2015
© 2015 Published by Global Science Publishing Group, USA

How to Cite this Article:

Abd Elsamad I. Elhewala, Samar G. Soliman, Alaa  A.  Labeeb, Waleed A. Mousa, and Dalia S. Seif. (2015). Serum and
synovial Interleukin-17A level in Rheumatoid arthritis patients and its relation to disease activity. Biolife, 3(3), pp 639-
643. doi:10.17812/blj.2015.3310

Link to this article: http://biolifejournal.com/10.17812_blj.2015.3310.html
Biolife
AN OFFICIAL PUBLICATION OF GLOBAL SCIENCE PUBLISHING GROUP, USA
International Quarterly Journal of Biology & Life Sciences
Impact
Factor

4.175
eISSN 2320-4257
Serum and synovial Interleukin-17A level in Rheumatoid arthritis patients and its relation to disease activity

Abd Elsamad I. Elhewala1, Samar G. Soliman2, Alaa  A.  Labeeb3, Waleed A. Mousa4, and Dalia S. Seif5

1Rheumatology, physical medicine and rehabilitation department, Zagazyg University, Egypt.
2,3,5 Rheumatology, Physical medicine and rehabilitation department, Menoufiya University, Egypt.
4 Radiology Department, Menoufiya University, Egypt.


Email:
sdalia30@yahoo.co.in
  Article Options
10.17812_blj2015.32.27
Copyright © 2015 by http://globalsciencepg.org/ ·  All Rights reserved  ·  E-Mail: editorbiolife@gmail.com